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Article

RUNX3 and T-Bet in Immunopathogenesis of Ankylosing Spondylitis—Novel Targets for Therapy?

10 Jan 2019

Abstract excerpt

Susceptibility to ankylosing spondylitis (AS) is polygenic with more than 100 genes identified to date. These include HLA-B27 and the aminopeptidases (ERAP1, ERAP2 and LNPEPS), which are involved in antigen processing and presentation to T-cells, and several genes (IL23R, IL6R, STAT3, JAK2, IL1R1/2, IL12B and IL7R) involved in IL23 driven pathways of inflammation. AS is also strongly associated with polymorphisms...

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Identifiers

PMID: 30687330
DOI: 10.3389/fimmu.2018.03132

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