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Article

From the Genetics of Ankylosing Spondylitis to New Biology and Drug Target Discovery.

Frontiers in immunology - 1 Jan 2021

Nancy Zaarour, Yan Li, Hui Shi, Paul Bowness, Liye Chen

Abstract excerpt

Genome-wide association studies (GWAS) have identified 113 single nucleotide polymorphisms (SNPs) affecting the risk of developing ankylosing spondylitis (AS), and an on-going GWAS study will likely identify 100+ new risk loci. The translation of genetic findings to novel disease biology and treatments has been difficult due to the following challenges: (1) difficulties in determining the causal genes regulated...

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Identifiers

PMID: 33679768
DOI: 10.3389/fimmu.2021.624632
PMCID: PMC7925991

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