Article
Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease.
PLoS genetics - 1 Feb 2017
Soderquest Katrina, Hertweck Arnulf, Giambartolomei Claudia, Henderson Stephen, Mohamed Rami, Goldberg Rimma, Perucha Esperanza, Franke Lude, Herrero Javier, Plagnol Vincent, Jenner Richard G, Lord Graham M
Abstract excerpt
The polarization of CD4+ T cells into distinct T helper cell lineages is essential for protective immunity against infection, but aberrant T cell polarization can cause autoimmunity. The transcription factor T-bet (TBX21) specifies the Th1 lineage and represses alternative T cell fates. Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) that may be causative for autoimmune...
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