Article

The Th1 cell regulatory circuitry is largely conserved between human and mouse

2021-01-12

Abstract excerpt

<h4>ABSTRACT</h4> Gene expression programmes controlled by lineage-determining transcription factors are often conserved between species. However, infectious diseases have exerted profound evolutionary pressure, and therefore the genes regulated by immune-specific transcription factors might be expected to exhibit greater divergence due to exposure to species-specific pathogens. T-bet (Tbx21) is the immune-specif...

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Literature Corpus work: 4125b1fc-cd68-5fb7-9a55-000b97abfe3d
DOI: 10.1101/2021.01.11.426266

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