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Polymorphonuclear Myeloid-Derived Suppressor Cells Promote Inflammation Progression of Rheumatoid Arthritis by Inducing Age-Associated B Cell Proliferation and Differentiation via the BAFF-Mediated SYK-ERK1/2 Pathway

2025-07-23

Abstract excerpt

<title>Abstract</title> <p>Background In rheumatoid arthritis (RA), both polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) and age-associated B cells (ABCs) are significantly elevated in affected joints and are closely linked to disease progression. However, their interaction remains poorly understood. This study aims to explore the regulatory role of PMN-MDSCs on ABCs and the underlying mechanisms,...

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Literature Corpus work
9fc73dad-5b9c-5169-8972-12f3d24cb7b6
DOI
10.21203/rs.3.rs-6846731/v1
Open publication

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Polymorphonuclear Myeloid-Derived Suppressor Cells Promote Inflammation Progression of Rheumatoid Arthritis by Inducing Age-Associated B Cell Proliferation and Differentiation via the BAFF-Mediated SYK-ERK1/2 PathwayDOI 10.21203/rs.3.rs-6846731/v1
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