Article
Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling.
Leukemia - 1 Oct 2016
Tremblay C S, Brown F C, Collett M, Saw J, Chiu S K, Sonderegger S E, Lucas S E, Alserihi R, Chau N, Toribio M L, McCormack M P, Chircop M, Robinson P J, Jane S M, Curtis D J
Abstract excerpt
Mutations in the DYNAMIN2 (DNM2) gene are frequently detected in human acute T-cell lymphoblastic leukemia (T-ALL), although the mechanisms linking these mutations to disease pathogenesis remain unknown. Using an ENU-based forward genetic screen for mice with erythroid phenotypes, we identified a heterozygous mouse line carrying a mutation in the GTPase domain of Dnm2 (Dnm2V265G) that induced a microcytic anemia....
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