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Article

Interleukin-7 receptor mutants initiate early T cell precursor leukemia in murine thymocyte progenitors with multipotent potential.

The Journal of experimental medicine - 7 Apr 2014

Treanor Louise M, Zhou Sheng, Janke Laura, Churchman Michelle L, Ma Zhijun, Lu Taihe, Chen Shann-Ching, Mullighan Charles G, Sorrentino Brian P

Abstract excerpt

Early T cell precursor acute lymphoblastic leukemia (ETP-ALL) exhibits lymphoid, myeloid, and stem cell features and is associated with a poor prognosis. Whole genome sequencing of human ETP-ALL cases has identified recurrent mutations in signaling, histone modification, and hematopoietic development genes but it remains to be determined which of these abnormalities are sufficient to initiate leukemia. We show...

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Source

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Identifiers

PMID: 24687960
DOI: 10.1084/jem.20122727
PMCID: PMC3978278

Genes

LMO2
NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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