Article
Mutations in the clathrin-assembly gene Picalm are responsible for the hematopoietic and iron metabolism abnormalities in fit1 mice.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jul 2003
Klebig Mitchell L, Wall Melissa D, Potter Mark D, Rowe Erica L, Carpenter Donald A, Rinchik Eugene M
Abstract excerpt
Recessive N-ethyl-N-nitrosourea (ENU)-induced mutations recovered at the fitness-1 (fit1) locus in mouse chromosome 7 cause hematopoietic abnormalities, growth retardation, and shortened life span, with varying severity of the defects in different alleles. Abnormal iron distribution and metabolism and frequent scoliosis have also been associated with an allele of intermediate severity (fit14R). We report that...
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