Article
Two dynamin-2 genes are required for normal zebrafish development.
PloS one - 1 Jan 2013
Gibbs Elizabeth M, Davidson Ann E, Trickey-Glassman Arden, Backus Carey, Hong Yu, Sakowski Stacey A, Dowling James J, Feldman Eva L
Abstract excerpt
Dynamin-2 (DNM2) is a large GTPase involved in clathrin-mediated endocytosis and related trafficking pathways. Mutations in human DNM2 cause two distinct neuromuscular disorders: centronuclear myopathy and Charcot-Marie-Tooth disease. Zebrafish have been shown to be an excellent animal model for many neurologic disorders, and this system has the potential to inform our understanding of DNM2-related disease....
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