Article

Evolutionary rewiring of the DNM2 proline-rich domain drives lineage-specific constraints in erythropoiesis

2026-03-23

Abstract excerpt

<h4>ABSTRACT</h4> Dynamin-2 (DNM2) is a ubiquitously expressed GTPase essential for membrane trafficking, yet how its evolution shapes tissue-specific functions remains unclear. Here, we generated a humanized mouse model in which murine Dnm2 is fully replaced by human DNM2 . Human DNM2 rescues the embryonic lethality of Dnm2 deletion but cannot sustain postnatal hematopoiesis, leading to fatal hemolytic anemia...

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Literature Corpus work: cce1f81d-dec3-5558-9225-564d9af322a9
DOI: 10.64898/2026.03.20.713161

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Evolutionary rewiring of the DNM2 proline-rich domain drives lineage-specific constraints in erythropoiesisDOI 10.64898/2026.03.20.713161Read

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