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Article

The impact of PICALM genetic variations on reserve capacity of posterior cingulate in AD continuum.

Scientific reports - 27 Apr 2016

Xu Wei, Wang Hui-Fu, Tan Lin, Tan Meng-Shan, Tan Chen-Chen, Zhu Xi-Chen, Miao Dan, Yu Wan-Jiang, Jiang Teng, Tan Lan, Yu Jin-Tai

Abstract excerpt

Phosphatidylinositolbinding clathrin assembly protein (PICALM) gene is one novel genetic player associated with late-onset Alzheimer's disease (LOAD), based on recent genome wide association studies (GWAS). However, how it affects AD occurrence is still unknown. Brain reserve hypothesis highlights the tolerant capacities of brain as a passive means to fight against neurodegenerations. Here, we took the baseline...

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Source

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Identifiers

PMID: 27117083
DOI: 10.1038/srep24480
PMCID: PMC4846810

Genes

PICALM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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