Article
Genetic variation in PICALM and Alzheimer's disease risk in Han Chinese.
Neurobiology of aging - 1 Apr 2014
Jiang Teng, Yu Jin-Tai, Tan Meng-Shan, Wang Hui-Fu, Wang Ying-Li, Zhu Xi-Chen, Zhang Wei, Tan Lan
Abstract excerpt
The current study was conducted to investigate the association of phosphatidylinositol-binding clathrin assembly protein gene (PICALM) with late-onset Alzheimer's disease (LOAD) risk in Han Chinese. We first sequenced PICALM for variants in a small sample (n = 100), and the selected variants were then genotyped in a larger cohort (n = 2292). Sequencing analysis identified 16 variants within PICALM including 5 new...
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