Article
The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzheimer disease risk and cerebrospinal fluid biomarker levels.
Archives of general psychiatry - 1 Feb 2011
Schjeide Brit-Maren M, Schnack Cathrin, Lambert Jean-Charles, Lill Christina M, Kirchheiner Julia, Tumani Hayrettin, Otto Markus, Tanzi Rudolph E, Lehrach Hans, Amouyel Philippe, von Arnim Christine A F, Bertram Lars
Abstract excerpt
CONTEXT: Two recent and simultaneously published genome-wide association studies independently implicated clusterin (CLU), complement receptor 1 (CR1), and phosphatidylinositol binding clathrin assembly protein (PICALM) as putative novel Alzheimer disease (AD) risk loci. Despite their strong statistical support, all 3 signals emerged from heterogeneous case-control populations and lack replication in different...
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