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Article

Constraints on Biological Mechanism from Disease Comorbidity Using Electronic Medical Records and Database of Genetic Variants.

PLoS computational biology - 1 Apr 2016

Bagley Steven C, Sirota Marina, Chen Richard, Butte Atul J, Altman Russ B

Abstract excerpt

Patterns of disease co-occurrence that deviate from statistical independence may represent important constraints on biological mechanism, which sometimes can be explained by shared genetics. In this work we study the relationship between disease co-occurrence and commonly shared genetic architecture of disease. Records of pairs of diseases were combined from two different electronic medical systems (Columbia,...

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Identifiers

PMID: 27115429
DOI: 10.1371/journal.pcbi.1004885
PMCID: PMC4846031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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