Patient stratification reveals the molecular basis of disease comorbidities

Abstract excerpt

Epidemiological evidence shows that some diseases tend to co-occur; more exactly, certain groups of patients with a given disease are at a higher risk of developing a specific secondary condition. Here we develop a new approach to generate a disease network that uses the accumulating RNA-seq data on human diseases to significantly match an unprecedented proportion of known comorbidities, providing plausible biolog...

Topics

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• Biomarkers
• Case-Control Studies
• Comorbidity
• Computational Biology
• Datasets as Topic
• Gene Expression Profiling
• Genetic Predisposition to Disease
• Phenotype

Identifiers and source

Literature Corpus work

fe861b3a-728c-5b48-80b0-0e166595e2c2

DOI

10.1101/2021.07.22.21260979