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Article

Genetic and functional characterization of disease associations explains comorbidity.

Scientific reports - 24 Jul 2017

Rubio-Perez Carlota, Guney Emre, Aguilar Daniel, Piñero Janet, Garcia-Garcia Javier, Iadarola Barbara, Sanz Ferran, Fernandez-Fuentes Narcís, Furlong Laura I, Oliva Baldo

Abstract excerpt

Understanding relationships between diseases, such as comorbidities, has important socio-economic implications, ranging from clinical study design to health care planning. Most studies characterize disease comorbidity using shared genetic origins, ignoring pathway-based commonalities between diseases. In this study, we define the disease pathways using an interactome-based extension of known disease-genes and...

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Identifiers

PMID: 28740175
DOI: 10.1038/s41598-017-04939-4
PMCID: PMC5524755

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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