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Article

Disentangling genetic and environmental risk factors for individual diseases from multiplex comorbidity networks.

Scientific reports - 23 Dec 2016

Klimek Peter, Aichberger Silke, Thurner Stefan

Abstract excerpt

Most disorders are caused by a combination of multiple genetic and/or environmental factors. If two diseases are caused by the same molecular mechanism, they tend to co-occur in patients. Here we provide a quantitative method to disentangle how much genetic or environmental risk factors contribute to the pathogenesis of 358 individual diseases, respectively. We pool data on genetic, pathway-based, and...

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Identifiers

PMID: 28008973
DOI: 10.1038/srep39658
PMCID: PMC5180180

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