Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Whole-Genome Sequencing of a Healthy Aging Cohort.

Cell - 5 May 2016

Erikson Galina A, Bodian Dale L, Rueda Manuel, Molparia Bhuvan, Scott Erick R, Scott-Van Zeeland Ashley A, Topol Sarah E, Wineinger Nathan E, Niederhuber John E, Topol Eric J, Torkamani Ali

Abstract excerpt

Studies of long-lived individuals have revealed few genetic mechanisms for protection against age-associated disease. Therefore, we pursued genome sequencing of a related phenotype-healthy aging-to understand the genetics of disease-free aging without medical intervention. In contrast with studies of exceptional longevity, usually focused on centenarians, healthy aging is not associated with known longevity...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Alzheimer Disease

Share to Cohort Studies

Share to Coronary Artery Disease

Share to Genome-Wide Association Study

Share to Longevity

Source

Open in PubMed Open full text

Identifiers

PMID: 27114037
DOI: 10.1016/j.cell.2016.03.022
PMCID: PMC4860090

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Whole-Genome Sequencing of a Healthy Aging Cohort.PMID 27114037Read ↗

Genetic variation in healthy oldest-old.Semantic proximity Read ↗

Genetics of healthy aging and longevity.Semantic proximity Read ↗

Rare genetic coding variants associated with human longevity and protection against age-related diseases.Semantic proximity Read ↗

Genetic variation and human aging: progress and prospects.Semantic proximity Read ↗

Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity.Semantic proximity Read ↗

Resilience to dominant genetic disease in the healthy elderlySemantic proximity Read ↗

Long-Lived Individuals Show a Lower Burden of Variants Predisposing to Age-Related Diseases and a Higher Polygenic Longevity Score.Semantic proximity Read ↗

Candidate gene resequencing to identify rare, pedigree-specific variants influencing healthy aging phenotypes in the long life family study.Semantic proximity Read ↗

The Medical Genome Reference Bank: a whole-genome data resource of 4,000 healthy elderly individuals. Rationale and cohort designSemantic proximity Read ↗

The genetics of exceptional human longevity.Semantic proximity Read ↗

Genetic signatures of exceptional longevity in humans.Semantic proximity Read ↗

Dissecting the Mechanisms Underlying Unusually Successful Human Health Span and Life Span.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.