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Article

Genetic variation and human aging: progress and prospects.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Mar 2007

Melzer David, Hurst Alison J, Frayling Tim

Abstract excerpt

The genetics of aging has seen extraordinary progress over the last few decades, with animal models suggesting key roles for a number of metabolic pathways. However, humans outlive laboratory models many times over, and only evidence from humans can ultimately identify the drivers of human aging. In this article we thematically review progress in identifying human genetic variants associated with longevity. We...

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Identifiers

PMID: 17389728
DOI: 10.1093/gerona/62.3.301

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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