Article
SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense.
EMBO reports - 1 Jun 2016
Zhou Lisha, Wang Fang, Sun Renqiang, Chen Xiufei, Zhang Mengli, Xu Qi, Wang Yi, Wang Shiwen, Xiong Yue, Guan Kun-Liang, Yang Pengyuan, Yu Hongxiu, Ye Dan
Abstract excerpt
Excess in mitochondrial reactive oxygen species (ROS) is considered as a major cause of cellular oxidative stress. NADPH, the main intracellular reductant, has a key role in keeping glutathione in its reduced form GSH, which scavenges ROS and thus protects the cell from oxidative damage. Here, we report that SIRT5 desuccinylates and deglutarylates isocitrate dehydrogenase 2 (IDH2) and glucose-6-phosphate...
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