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Article

Protein hypoacylation induced by Sirt5 overexpression has minimal metabolic effect in mice.

Biochemical and biophysical research communications - 10 Sept 2018

Bentley Nicholas L, Fiveash Corrine E, Osborne Brenna, Quek Lake-Ee, Ogura Masahito, Inagaki Nobuya, Cooney Gregory J, Polly Patsie, Montgomery Magdalene K, Turner Nigel

Abstract excerpt

Sirtuins are a family of evolutionary conserved enzymes that dynamically regulate cellular physiology. Mammals have 7 sirtuins, which are located in different cellular compartments. Sirt5, a sirtuin isoform located in multiple subcellular sites, is involved in regulating a diverse range of cellular and metabolic processes through the removal of a range of acyl-lysine modifications on target proteins. Loss of...

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Identifiers

PMID: 30017194
DOI: 10.1016/j.bbrc.2018.07.047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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