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Article

SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks.

Cell metabolism - 3 Dec 2013

Rardin Matthew J, He Wenjuan, Nishida Yuya, Newman John C, Carrico Chris, Danielson Steven R, Guo Ailan, Gut Philipp, Sahu Alexandria K, Li Biao, Uppala Radha, Fitch Mark, Riiff Timothy, Zhu Lei, Zhou Jing, Mulhern Daniel, Stevens Robert D, Ilkayeva Olga R, Newgard Christopher B, Jacobson Matthew P, Hellerstein Marc, Goetzman Eric S, Gibson Bradford W, Verdin Eric

Abstract excerpt

Reversible posttranslational modifications are emerging as critical regulators of mitochondrial proteins and metabolism. Here, we use a label-free quantitative proteomic approach to characterize the lysine succinylome in liver mitochondria and its regulation by the desuccinylase SIRT5. A total of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24315375
DOI: 10.1016/j.cmet.2013.11.013
PMCID: PMC4105152

Genes

SIRT5
HMGCS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24315375-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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