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Article

SIRT5 desuccinylates and activates SOD1 to eliminate ROS.

Biochemical and biophysical research communications - 8 Nov 2013

Lin Zhi-Feng, Xu Hong-Bing, Wang Jian-Yun, Lin Qiang, Ruan Zhen, Liu Fa-Bing, Jin Wang, Huang Hai-Hua, Chen Xi

Abstract excerpt

Cu/Zn superoxide dismutase (SOD1) is a key antioxidant enzyme. Deficiency of SOD1 is associated with various human diseases, including cancer. Here, we report that SOD1 is succinylated and that succinylation decreases its activity. SIRT5 binds to, desuccinylates and activates SOD1. SOD1-mediated ROS reduction is increased when SIRT5 is co-expressed. Furthermore, mutation of the SOD1 succinylation site inhibits...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24140062
DOI: 10.1016/j.bbrc.2013.10.033

Genes

SOD1
SIRT5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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