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Article

Oxidative stress activates SIRT2 to deacetylate and stimulate phosphoglycerate mutase.

Cancer research - 1 Jul 2014

Xu Yanping, Li Fulong, Lv Lei, Li Tingting, Zhou Xin, Deng Chu-Xia, Guan Kun-Liang, Lei Qun-Ying, Xiong Yue

Abstract excerpt

Glycolytic enzyme phosphoglycerate mutase (PGAM) plays an important role in coordinating energy production with generation of reducing power and the biosynthesis of nucleotide precursors and amino acids. Inhibition of PGAM by small RNAi or small molecule attenuates cell proliferation and tumor growth. PGAM activity is commonly upregulated in tumor cells, but how PGAM activity is regulated in vivo remains poorly...

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Share to Acetylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24786789
DOI: 10.1158/0008-5472.CAN-13-3615
PMCID: PMC4303242

Genes

PGAM2
SIRT2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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