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Article

Glucose-6-phosphate dehydrogenase modulates cytosolic redox status and contractile phenotype in adult cardiomyocytes.

Circulation research - 25 Jul 2003

Jain Mohit, Brenner Daniel A, Cui Lei, Lim Chee Chew, Wang Bo, Pimentel David R, Koh Stanley, Sawyer Douglas B, Leopold Jane A, Handy Diane E, Loscalzo Joseph, Apstein Carl S, Liao Ronglih

Abstract excerpt

Reactive oxygen species (ROS)-mediated cell injury contributes to the pathophysiology of cardiovascular disease and myocardial dysfunction. Protection against ROS requires maintenance of endogenous thiol pools, most importantly, reduced glutathione (GSH), by NADPH. In cardiomyocytes, GSH resides in two separate cellular compartments: the mitochondria and cytosol. Although mitochondrial GSH is maintained largely...

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PMID: 12829617
DOI: 10.1161/01.RES.0000083489.83704.76

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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