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Mitochondrial sirtuins in stem cells and cancer

18 Apr 2021

Abstract excerpt

The mammalian sirtuin family consists of seven proteins, three of which (SIRT3, SIRT4, and SIRT5) localise specifically within mitochondria and preserve mitochondrial function and homeostasis. Mitochondrial sirtuins are involved in diverse functions such as deacetylation, ADP-ribosylation, demalonylation and desuccinylation, thus affecting various aspects of cell fate. Intriguingly, mitochondrial sirtuins are...

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PMID: 33866670
DOI: 10.1111/febs.15879

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