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Article

Metabolic characterization of a Sirt5 deficient mouse model.

Scientific reports - 30 Sept 2013

Yu Jiujiu, Sadhukhan Sushabhan, Noriega Lilia G, Moullan Norman, He Bin, Weiss Robert S, Lin Hening, Schoonjans Kristina, Auwerx Johan

Abstract excerpt

Sirt5, localized in the mitochondria, is a member of sirtuin family of NAD⁺-dependent deacetylases. Sirt5 was shown to deacetylate and activate carbamoyl phosphate synthase 1. Most recently, Sirt5 was reported to be the predominant protein desuccinylase and demalonylase in the mitochondria because the ablation of Sirt5 enhanced the global succinylation and malonylation of mitochondrial proteins, including many...

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Identifiers

PMID: 24076663
DOI: 10.1038/srep02806
PMCID: PMC3786297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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