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The Redox Role of G6PD in Cell Growth, Cell Death, and Cancer

8 Sept 2019

Abstract excerpt

The generation of reducing equivalent NADPH via glucose-6-phosphate dehydrogenase (G6PD) is critical for the maintenance of redox homeostasis and reductive biosynthesis in cells. NADPH also plays key roles in cellular processes mediated by redox signaling. Insufficient G6PD activity predisposes cells to growth retardation and demise. Severely lacking G6PD impairs embryonic development and delays organismal...

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PMID: 31500396
DOI: 10.3390/cells8091055

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