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Article

Psoriasis Plays a Wild CARD.

The Journal of investigative dermatology - 1 Sept 2018

Van Nuffel Elien, Afonina Inna S, Beyaert Rudi

Abstract excerpt

Rare autosomal mutations in CARD14 have previously been linked to psoriasis susceptibility in humans, but their pathogenic role had not been shown. Mellett et al. generated mice harboring the patient-derived gain-of-function Card14ΔE138 mutation and showed that hyperactivation of CARD14 alone is sufficient to induce immunopathogenic mechanisms that are responsible for psoriasis, which is driven by the IL-17/IL-23...

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Source

Identifiers

PMID: 30143077
DOI: 10.1016/j.jid.2018.05.001

Genes

CARD14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Psoriasis Plays a Wild CARD.PMID 30143077Read ↗

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CARD14 alterations and psoriasis: are psoriasis and related disorders genetic autoinflammatory diseases?Semantic proximity Read ↗

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Palmoplantar Pustular Psoriasis Is Associated with Missense Variants in CARD14, but Not with Loss-of-Function Mutations in IL36RN in European PatientsSemantic proximity Read ↗

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