Article
CARD14E138A signalling in keratinocytes induces TNF-dependent skin and systemic inflammation.
eLife - 29 Jun 2020
Manils Joan, Webb Louise V, Howes Ashleigh, Janzen Julia, Boeing Stefan, Bowcock Anne M, Ley Steven C
Abstract excerpt
To investigate how the CARD14E138A psoriasis-associated mutation induces skin inflammation, a knock-in mouse strain was generated that allows tamoxifen-induced expression of the homologous Card14E138A mutation from the endogenous mouse Card14 locus. Heterozygous expression of CARD14E138A rapidly induced skin acanthosis, immune cell infiltration and expression of psoriasis-associated pro-inflammatory genes....
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