Article
Serotonin transporter: gene, genetic disorders, and pharmacogenetics.
Molecular interventions - 1 Apr 2004
Murphy Dennis L, Lerner Alicja, Rudnick Gary, Lesch Klaus-Peter
Abstract excerpt
The highly evolutionarily conserved serotonin transporter (SERT) regulates the entire serotoninergic system and its receptors via modulation of extracellular fluid serotonin concentrations. Differences in SERT expression and function produced by three SERT genes and their variants show associations with multiple human disorders. Screens of DNA from patients with autism, ADHD, bipolar disorder, and Tourette's...
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