Serotonin transporter: gene, genetic disorders, and pharmacogenetics.

doi:10.1124/mi.4.2.8

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Article

Serotonin transporter: gene, genetic disorders, and pharmacogenetics.

Molecular interventions - 1 Apr 2004

Murphy Dennis L, Lerner Alicja, Rudnick Gary, Lesch Klaus-Peter

Abstract excerpt

The highly evolutionarily conserved serotonin transporter (SERT) regulates the entire serotoninergic system and its receptors via modulation of extracellular fluid serotonin concentrations. Differences in SERT expression and function produced by three SERT genes and their variants show associations with multiple human disorders. Screens of DNA from patients with autism, ADHD, bipolar disorder, and Tourette's...

Topics

Amino Acid Sequence
Animals
Brain
Evolution, Molecular
Genetic Diseases, Inborn
Genetic Predisposition to Disease
Humans
Molecular Sequence Data
Nervous System Diseases
Pharmacogenetics
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Positron-Emission Tomography

Sequence Alignment

Sequence Homology, Amino Acid

Serotonin

Serotonin Plasma Membrane Transport Proteins

Selective Serotonin Reuptake Inhibitors

Tomography, Emission-Computed, Single-Photon

Source

Open in PubMed

Identifiers

PMID: 15087484
DOI: 10.1124/mi.4.2.8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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