Article
Breast Cancer Heterogeneity Examined by High-Sensitivity Quantification of PIK3CA, KRAS, HRAS, and BRAF Mutations in Normal Breast and Ductal Carcinomas.
Neoplasia (New York, N.Y.) - 1 Apr 2016
Myers Meagan B, Banda Malathi, McKim Karen L, Wang Yiying, Powell Michael J, Parsons Barbara L
Abstract excerpt
Mutant cancer subpopulations have the potential to derail durable patient responses to molecularly targeted cancer therapeutics, yet the prevalence and size of such subpopulations are largely unexplored. We employed the sensitive and quantitative Allele-specific Competitive Blocker PCR approach to characterize mutant cancer subpopulations in ductal carcinomas (DCs), examining five specific hotspot point mutations...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.