Article
PIK3CA mutation profiling in patients with breast cancer, using a highly sensitive detection system.
Cancer science - 1 Aug 2018
Shimoi Tatsunori, Hamada Akinobu, Yamagishi Marifu, Hirai Mitsuharu, Yoshida Masayuki, Nishikawa Tadaaki, Sudo Kazuki, Shimomura Akihiko, Noguchi Emi, Yunokawa Mayu, Yonemori Kan, Shimizu Chikako, Kinoshita Takayuki, Fukuda Takahiro, Fujiwara Yasuhiro, Tamura Kenji
Abstract excerpt
PIK3CA mutations are common activating mutations associated with breast cancer (occurring in 20-30% of all cases) and are potent predictive markers for responses to PI3K inhibitors. Thus, it is important to develop sensitive methods to detect these mutations. We established a novel detection method using a quenching probe (QP) system to identify PIK3CA mutations, using DNA from 309 breast cancer tissues. In a...
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