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Article

ACB-PCR Quantification of Low-Frequency Hotspot Cancer-Driver Mutations.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2020

Myers Meagan B, McKim Karen L, Wang Yiying, Banda Malathi, Parsons Barbara L

Abstract excerpt

Allele-specific competitive blocker PCR (ACB-PCR) is a sensitive and quantitative approach for the selective amplification of a specific base substitution. Using the ACB-PCR technique, hotspot cancer-driver mutations (tumor-relevant mutations in oncogenes and tumor suppressor genes, which confer a selective growth advantage) are being developed as quantitative biomarkers of cancer risk. ACB-PCR employs a...

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PMID: 31989569
DOI: 10.1007/978-1-0716-0223-2_23

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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