Article
Disturbing immune homeostasis by neutrophil loss of Uba1 induces VEXAS-like autoinflammatory disease in mice
2025-04-15
Abstract excerpt
<h4>ABSTRACT</h4> <h4>Objective</h4> VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome is an identified haemato-rheumatoid disease caused by somatic UBA1 mutations in hematopoietic stem cells. We report Uba1 loss in various mouse hematopoietic cell types leads to diverse effects, with approximately 70% Uba1 depletion in neutrophils inducing non-lethal VEXAS-like symptoms. <h4>Methods</...
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Identifiers and source
- Literature Corpus work
- 143e67a7-7ae9-5507-9231-d322d7d198a0
- DOI
- 10.1101/2025.04.09.648068