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Article

Cardiovascular Risk Factors and Ischemic Heart Disease: Is the Confluence of Risk Factors Greater Than the Parts? A Genetic Approach.

Circulation. Cardiovascular genetics - 1 Jun 2016

Elosua Roberto, Lluís-Ganella Carla, Subirana Isaac, Havulinna Aki, Läll Kristi, Lucas Gavin, Sayols-Baixeras Sergi, Pietilä Arto, Alver Maris, Cabrera de León Antonio, Sentí Mariano, Siscovick David, Mellander Olle, Fischer Krista, Salomaa Veikko, Marrugat Jaume

Abstract excerpt

BACKGROUND: Cardiovascular risk factors tend to aggregate. The biological and predictive value of this aggregation is questioned and genetics could shed light on this debate. Our aims were to reappraise the impact of risk factor confluence on ischemic heart disease (IHD) risk by testing whether genetic risk scores (GRSs) associated with these factors interact on an additive or multiplicative scale, and to...

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Identifiers

PMID: 27103211
DOI: 10.1161/CIRCGENETICS.115.001255
PMCID: PMC4917423

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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