Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic interaction effects reveal lipid-metabolic and inflammatory pathways underlying common metabolic disease risks.

BMC medical genomics - 20 Jun 2018

Woo Hyung Jun, Reifman Jaques

Abstract excerpt

BACKGROUND: Common metabolic diseases, including type 2 diabetes, coronary artery disease, and hypertension, arise from disruptions of the body's metabolic homeostasis, with relatively strong contributions from genetic risk factors and substantial comorbidity with obesity. Although genome-wide association studies have revealed many genomic loci robustly associated with these diseases, biological interpretation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Predisposition to Disease
Share to Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotyping Techniques

Share to Inflammation

Share to Lipid Metabolism

Share to Metabolic Diseases

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 29925367
DOI: 10.1186/s12920-018-0373-7
PMCID: PMC6011398

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic interaction effects reveal lipid-metabolic and inflammatory pathways underlying common metabolic disease risks.PMID 29925367Read ↗

Partitioned polygenic scores show mechanistic heterogeneity in type 2 diabetes and hypertension comorbidity.Semantic proximity Read ↗

Exploring the shared genetic landscape of diabetes and cardiovascular disease: findings and future implicationsSemantic proximity Read ↗

Genetic determinants of cardiometabolic risk: a proposed model for phenotype association and interaction.Semantic proximity Read ↗

Gene–gene and gene–environment interactions defining lipid-related traitsSemantic proximity Read ↗

Mechanistic Heterogeneity in Type 2 Diabetes and Hypertension Comorbidity Revealed with Partitioned Polygenic ScoresSemantic proximity Read ↗

Can genetic pleiotropy replicate common clinical constellations of cardiovascular disease and risk?Semantic proximity Read ↗

Shared Genetic Contribution of Type 2 Diabetes and Cardiovascular Disease: Implications for Prognosis and Treatment.Semantic proximity Read ↗

Multi-omics uncovers the pleiotropic genetic mechanisms linking MASLD and cardiometabolic syndromes.Semantic proximity Read ↗

Effects of interacting networks of cardiovascular risk genes on the risk of type 2 diabetes mellitus (the CODAM study).Semantic proximity Read ↗

Decoding the genetic crosstalk network for cardiometabolic diseases and metabolic traitsSemantic proximity Read ↗

Multi-Trait Genome-Wide Association Study of Atherosclerosis Detects Novel Pleiotropic LociSemantic proximity Read ↗

Disease patterns of coronary heart disease and type 2 diabetes harbored distinct and shared genetic architecture.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.