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Article

Genetic and modifiable risk factors combine multiplicatively in common disease.

Clinical research in cardiology : official journal of the German Cardiac Society - 1 Feb 2023

Pang Shichao, Yengo Loic, Nelson Christopher P, Bourier Felix, Zeng Lingyao, Li Ling, Kessler Thorsten, Erdmann Jeanette, Mägi Reedik, Läll Kristi, Metspalu Andres, Mueller-Myhsok Bertram, Samani Nilesh J, Visscher Peter M, Schunkert Heribert

Abstract excerpt

BACKGROUND: The joint contribution of genetic and environmental exposures to noncommunicable diseases is not well characterized. OBJECTIVES: We modeled the cumulative effects of common risk alleles and their prevalence variations with classical risk factors. METHODS: We analyzed mathematically and statistically numbers and effect sizes of established risk alleles for coronary artery disease (CAD) and other...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35987817
DOI: 10.1007/s00392-022-02081-4
PMCID: PMC9898372

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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