Article
Genetic predisposition to coronary heart disease and stroke using an additive genetic risk score: a population-based study in Greece.
Atherosclerosis - 1 May 2012
Yiannakouris N, Katsoulis M, Dilis V, Parnell L D, Trichopoulos D, Ordovas J M, Trichopoulou A
Abstract excerpt
OBJECTIVE: To determine the extent to which the risk for incident coronary heart disease (CHD) increases in relation to a genetic risk score (GRS) that additively integrates the influence of high-risk alleles in nine documented single nucleotide polymorphisms (SNPs) for CHD, and to examine whether this GRS also predicts incident stroke. METHODS: Genotypes at nine CHD-relevant SNPs were determined in 494 cases of...
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