Article
Deficiency of Dab2 (Disabled Homolog 2) in Myeloid Cells Exacerbates Inflammation in Liver and Atherosclerotic Plaques in LDLR (Low-Density Lipoprotein Receptor)-Null Mice-Brief Report.
Arteriosclerosis, thrombosis, and vascular biology - 1 May 2018
Adamson Samantha E, Polanowska-Grabowska Renata, Marqueen Kathryn, Griffiths Rachael, Angdisen Jerry, Breevoort Sarah R, Schulman Ira G, Leitinger Norbert
Abstract excerpt
OBJECTIVE: Inflammatory macrophages promote the development of atherosclerosis. We have identified the adaptor protein Dab2 (disabled homolog 2) as a regulator of phenotypic polarization in macrophages. The absence of Dab2 in myeloid cells promotes an inflammatory phenotype, but the impact of myeloid Dab2 deficiency on atherosclerosis has not been shown. APPROACH AND RESULTS: To determine the role of myeloid Dab2...
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