c-Jun N-Terminal Kinases (JNKs) Are Critical Mediators of Osteoblast Activity In Vivo

Abstract excerpt

ABSTRACT The c-Jun N-terminal kinases (JNKs) are ancient and evolutionarily conserved regulators of proliferation, differentiation, and cell death responses. Currently, in vitro studies offer conflicting data about whether the JNK pathway augments or represses osteoblast differentiation, and the contribution of the JNK pathway to regulation of bone mass in vivo remains unclear. Here we show that Jnk1–/– mice...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Melanoma and MAPK Pathways
• Share to Bone health and treatments
• Share to Bone Metabolism and Diseases