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Article

Macrophage apolipoprotein E reduces atherosclerosis and prevents premature death in apolipoprotein E and scavenger receptor-class BI double-knockout mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2006

Yu Hong, Zhang Wenwu, Yancey Patricia G, Koury Mark J, Zhang Youmin, Fazio Sergio, Linton MacRae F

Abstract excerpt

OBJECTIVE: Mice null for both apolipoprotein (apo)E and scavenger receptor (SR)-BI (DKO) develop severe hypercholesterolemia, occlusive coronary atherosclerosis, myocardial infarction, and premature death. The current study examines the ability of macrophage apoE to improve the dyslipidemia, reduce atherosclerosis, and rescue the lethal phenotype of DKO mice. METHODS AND RESULTS: Initially, bone marrow...

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Identifiers

PMID: 16269665
DOI: 10.1161/01.ATV.0000194096.89476.73

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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