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Article

SIRT2 decreases atherosclerotic plaque formation in low-density lipoprotein receptor-deficient mice by modulating macrophage polarization.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Jan 2018

Zhang BuChun, Ma YanFeng, Xiang ChuHan

Abstract excerpt

Compelling evidence has demonstrated that the M1 macrophage phenotype is central to atherosclerotic lesion development. SIRT2, an NAD+-dependent sirtuin deacetylase, is involved in modulating macrophage polarization. However, the role of SIRT2 in atherosclerotic progression remains unknown. Female LDL receptor knockout (LDLr-/-) mice were randomly divided into four groups for treatment with saline, empty...

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Source

Identifiers

PMID: 29145149
DOI: 10.1016/j.biopha.2017.11.061

Genes

SIRT2

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