Article
Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners.
PloS one - 1 Jan 2016
Alves da Silva Antônio Francisco, Machado Filipe Brum, Pavarino Érika Cristina, Biselli-Périco Joice Matos, Zampieri Bruna Lancia, da Silva Francisco Junior Ronaldo, Mozer Rodrigues Pedro Thyago, Terra Machado Douglas, Santos-Rebouças Cíntia Barros, Gomes Fernandes Maria, Chuva de Sousa Lopes Susana Marina, Lopes Rios Álvaro Fabricio, Medina-Acosta Enrique
Abstract excerpt
The supernumerary chromosome 21 in Down syndrome differentially affects the methylation statuses at CpG dinucleotide sites and creates genome-wide transcriptional dysregulation of parental alleles, ultimately causing diverse pathologies. At present, it is unknown whether those effects are dependent or independent of the parental origin of the nondisjoined chromosome 21. Linkage analysis is a standard method for...
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