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Article

Trans-acting epigenetic effects of chromosomal aneuploidies: lessons from Down syndrome and mouse models.

Epigenomics - 1 Feb 2017

Do Catherine, Xing Zhuo, Yu Y Eugene, Tycko Benjamin

Abstract excerpt

An important line of postgenomic research seeks to understand how genetic factors can influence epigenetic patterning. Here we review epigenetic effects of chromosomal aneuploidies, focusing on findings in Down syndrome (DS, trisomy 21). Recent work in human DS and mouse models has shown that the extra chromosome 21 acts in trans to produce epigenetic changes, including differential CpG methylation (DS-DM), in...

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Identifiers

PMID: 27911079
DOI: 10.2217/epi-2016-0138
PMCID: PMC5549717

Genes

ERG
ETS2
GABPA
OLIG2
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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