Article
DNA-Methylation Patterns in Trisomy 21 Using Cells from Monozygotic Twins.
PloS one - 1 Jan 2015
Sailani M Reza, Santoni Federico A, Letourneau Audrey, Borel Christelle, Makrythanasis Periklis, Hibaoui Youssef, Popadin Konstantin, Bonilla Ximena, Guipponi Michel, Gehrig Corinne, Vannier Anne, Carre-Pigeon Frederique, Feki Anis, Nizetic Dean, Antonarakis Stylianos E
Abstract excerpt
DNA methylation is essential in mammalian development. We have hypothesized that methylation differences induced by trisomy 21 (T21) contribute to the phenotypic characteristics and heterogeneity in Down syndrome (DS). In order to determine the methylation differences in T21 without interference of the interindividual genomic variation, we have used fetal skin fibroblasts from monozygotic (MZ) twins discordant...
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