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Article

Disease specific characteristics of fetal epigenetic markers for non-invasive prenatal testing of trisomy 21

8 Jan 2014

Abstract excerpt

BACKGROUND: Non-invasive prenatal testing of trisomy 21 (T21) is being actively investigated using fetal-specific epigenetic markers (EPs) that are present in maternal plasma. Recently, 12 EPs on chromosome 21 were identified based on tissue-specific epigenetic characteristics between placenta and blood, and demonstrated excellent clinical performance in the non-invasive detection of fetal T21. However, the...

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Share to Epigenetics and DNA Methylation
Share to Fetal and Pediatric Neurological Disorders
Share to Prenatal Screening and Diagnostics

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PMID: 24397966
DOI: 10.1186/1755-8794-7-1

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