Article

Selective chr21 homolog silencing reveals polymorphisms influence the epigenetic silencing and functional dosage of RWDD2B

2025-09-18

Abstract excerpt

<h4>Summary</h4> Polymorphisms that affect chr21 gene expression have significance for both variable severity in Down syndrome and common multifactorial conditions. Results here demonstrate “selective homolog silencing” in cells from even one individual can provide a valuable complement to large studies. In trisomic iPSC subclones that silence different chr21 homologs (via XIST -based silencing), we discovered u...

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Literature Corpus work: f5044a1e-d1e9-5ec7-8e17-29b8e7b8d04c
DOI: 10.1101/2025.09.17.676855

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