Genome-wide parent-of-origin DNA methylation analysis reveals the intricacies of human imprinting and suggests a germline methylation-independent mechanism of establishment.

doi:10.1101/gr.164913.113

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Genome-wide parent-of-origin DNA methylation analysis reveals the intricacies of human imprinting and suggests a germline methylation-independent mechanism of establishment.

Genome research - 1 Apr 2014

Court Franck, Tayama Chiharu, Romanelli Valeria, Martin-Trujillo Alex, Iglesias-Platas Isabel, Okamura Kohji, Sugahara Naoko, Simón Carlos, Moore Harry, Harness Julie V, Keirstead Hans, Sanchez-Mut Jose Vicente, Kaneki Eisuke, Lapunzina Pablo, Soejima Hidenobu, Wake Norio, Esteller Manel, Ogata Tsutomu, Hata Kenichiro, Nakabayashi Kazuhiko, Monk David

Abstract excerpt

Differential methylation between the two alleles of a gene has been observed in imprinted regions, where the methylation of one allele occurs on a parent-of-origin basis, the inactive X-chromosome in females, and at those loci whose methylation is driven by genetic variants. We have extensively characterized imprinted methylation in a substantial range of normal human tissues, reciprocal genome-wide uniparental...

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PMID: 24402520
DOI: 10.1101/gr.164913.113
PMCID: PMC3975056

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