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The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis

5 Feb 2021

Abstract excerpt

Abstract Down syndrome is associated with genome-wide perturbation of gene expression, which may be mediated by epigenetic changes. We perform an epigenome-wide association study on neonatal bloodspots comparing 196 newborns with Down syndrome and 439 newborns without Down syndrome, adjusting for cell-type heterogeneity, which identifies 652 epigenome-wide significant CpGs (P < 7.67 × 10−8) and 1,052...

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PMID: 33547282
DOI: 10.1038/s41467-021-21064-z

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